She made her debut in the Telugu film Josh , opposite Naga Chaitanya. She rose to fame starring in her second and her first successful Tamil film Ko , opposite Jiiva and Piaa Bajpai with ko. Karthika was born to former Indian actress Radha , and is the niece of actress Ambika.
She has two siblings, a brother and a sister, Thulasi Nair , who is also a South Indian actress. She did her schooling in Podar International School  in Mumbai and studied for an international degree in Business from college affiliated to London School of Economics. She made her acting debut at the age of 17 in the Telugu film Josh , opposite Naga Chaitanya. Though the film received mixed reviews, her performance as Vidya, an elementary school teacher desperate to attend college was received well.
Her second movie was in Tamil , called Ko , directed by famous film director K. Anand , with Jiiva and Piaa Bajpai in lead roles, which did very well at the box office. Her performance as Renuka Narayanan, an investigative journalist , who exposes the blunders of politicians was hugely applauded. She then appeared in the Malayalam film Makaramanju , directed by Lenin Rajeendran, starring alongside ace cinematographer and director Santosh Sivan. She donned a dual role, one of a painting model, Sugandha Bai and Urvashi , the Celestial beauty.
Her first ever dual role was well received and critics raved about her performance. British director Danny Boyle was highly impressed with her work in the film. In , she appeared in a single Telugu film Dammu , directed by Boyapati Srinu , in a limited glamorous role.
Her performance and the movie received mixed reviews and ended up to be a commercial failure. She was paired with N. Rama Rao Jr. Her performance as Surekha, a mute Christian young widow who works in Indian Revenue Service was well received and so is the film. Later, she appeared in the titular role in the Tamil film Annakodi , directed by legendary filmmaker P. Though the film received negative reviews, her performance as a damsel in distress received positive response.
She made her Kannada debut with Brindavana , a remake of Telugu blockbuster Brindavanam. The film repeated the success of the original. In the film, she was paired with Darshan.
In , she appeared in her third Telugu film Brother of Bommali , where she played Lucky, the streetwise tomboy twin sister of Allari Naresh's character. In the film, she has donned a full length comic role. Her performance received high critical acclaim and she received her first ever Filmfare nomination in the category of Filmfare Award for Best Supporting Actress -Telugu at 62nd Filmfare Awards South.
Jananathan , alongside Arya , Vijay Sethupathi and Shaam. Her performance as Kuyili, a mastermind behind a prison break plan received positive response. The film received commercial success and critical acclaim. Her portrayal of Kuyili is cited as complete deprival from regular commercial heroine characterisations. Her much delayed film Vaa Deal , starring Arun Vijay is yet to be released.
In the series, she played Devasena , a warrior queen, which was well received by both audience and critics. The show aired its last on 10 September The role of Devasena is considered one of the best and strongest characters of Indian Television.
She gained a huge following and much appreciation among the television audience. From Wikipedia, the free encyclopedia. Indian actress. This biography of a living person needs additional citations for verification. Please help by adding reliable sources. Contentious material about living persons that is unsourced or poorly sourced must be removed immediately , especially if potentially libelous or harmful. The Times Of India.